What is the average Staff Nurse salary for Greenville, SC?
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As of July 01, 2026, the average Staff Nurse salary in Greenville, SC is $87,444. The chart below represents localized salaries for some of our most popular Staff Nurse job titles in Greenville, SC. Salaries can vary greatly depending on numerous factors, including position, location, years of experience, and level of education. Salary.com’s team of Certified Compensation Professionals analyzed survey data collected from thousands of HR departments at companies of all sizes and industries to compile a range of salaries for various Staff Nurse job titles in Greenville, SC. Apply your personal criteria to one of the job titles below to get your personalized salary estimate.
Staff Nurse Salaries in Greenville, SC
| Job Title | Salary | Hourly Rate | Location | Date Updated |
| Staff Nurse - RN II | $84,486 | $40.62 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN III | $97,658 | $46.95 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN - Occupational Health | $88,687 | $42.64 | Greenville, SC | July 01, 2026 |
| Staff Nurse Senior- RN - Occupational Health | $99,864 | $48.01 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN I | $69,559 | $33.44 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN - CCU | $82,916 | $39.86 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN - Flight Transport | $96,258 | $46.28 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN - Wound and Enterostomal | $97,956 | $47.09 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN - Emergency Room | $76,947 | $36.99 | Greenville, SC | July 01, 2026 |
| Staff Nurse - RN - Psychiatric | $84,864 | $40.80 | Greenville, SC | July 01, 2026 |
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN II Salaries in Greenville, SCAlternate Job Titles:Intermediate Registered Nurse - Staff, Registered Nurse (RN), Level 2, Staff Nurse - RN IICategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May focus on a specific medical specialty. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4-7 years of related experience. Staff Nurse - RN III Salaries in Greenville, SCAlternate Job Titles:Registered Nurse (RN), Level 3, Senior Registered Nurse - Staff, Staff Nurse - RN IIICategory : Healthcare - Nursing
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Provides professional nursing care to on-site employees. Treats occupational injuries and illnesses, referring patients to emergency care facilities or outside medical resources as needed. Performs pre-employment physical examinations, including vision and hearing screenings, blood work, and other related tests. Maintains employee medical records and ensures that record keeping procedures comply with legal and confidentiality requirements. May be responsible for administering flu vaccinations, workers' compensation, disability, and/or employee health and safety training programs. Requires a bachelor's degree in nursing or equivalent. Requires a Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN - Occupational Health Salaries in Greenville, SCAlternate Job Titles:Occupational Health Unit Nurse, RN - Occupational Health, Staff Nurse - RN - Occupational Health
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Provides professional nursing care to on-site employees. Treats occupational injuries and illnesses, referring patients to emergency care facilities or outside medical resources as needed. Performs pre-employment physical examinations, including vision and hearing screenings, blood work, and other related tests. Maintains employee medical records and ensures that record-keeping procedures comply with legal and confidentiality requirements. May be responsible for administering flu vaccination, workers' compensation, disability, and/or employee health and safety training programs. Typically requires a bachelor's degree in nursing or equivalent. Requires a Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4-7 years of related experience. Staff Nurse Senior- RN - Occupational Health Salaries in Greenville, SCAlternate Job Titles:Senior Occupational Health Unit Nurse, Senior RN - Occupational Health, Staff Nurse Senior- RN - Occupational Health
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is closely managed. Works on projects/matters of limited complexity in a support role. Typically requires 0-2 years of related experience. Staff Nurse - RN I Salaries in Greenville, SCAlternate Job Titles:Entry Registered Nurse - Staff, Registered Nurse (RN), Level 1, Staff Nurse - RN ICategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients in the critical/coronary care unit. Performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress, records observations in patient medical record, and updates attending physician directly when necessary. Typically requires a bachelor's degree. Requires Registered Nurse (RN). Requires Advanced Cardiac Life Support (ACLS). Typically reports to a manager or head of a unit/department. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - CCU Salaries in Greenville, SCAlternate Job Titles:Critical Care Nurse, Registered Nurse (RN), Critical Care Unit (CCU), Staff Nurse - RN - CCUCategory : Healthcare - Nursing
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Provides professional nursing care to critically injured or ill patients throughout all phases of emergency ground and air transportation. Evaluates and treats patients prior to and during transport, ensuring patient safety and implementing life support measures as needed. Monitors patient condition, documents nursing care, and reports patient status to clinical staff at receiving medical facility. Typically requires a bachelor's degree in nursing. Typically reports to a manager or head of a unit/department. Typically requires Advanced Cardiovascular Life Support (ACLS) and Basic Life Support (BLS) certification. May require Certified Flight Registered Nurse (CFRN) certification. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Flight Transport Salaries in Greenville, SCAlternate Job Titles:Critical Care Transport Nurse, Flight Nurse, Staff Nurse - RN - Flight Transport
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Aids hospital staff and physicians in the care of patients with stomas, draining wounds, fistulae, incontinence, or potential or actual tissue trauma. Manages patients with post-operative surgical wounds requiring packing or negative pressure wound therapy (NPWT), pressure ulcers and vascular ulcers. Provides support and education to patients and their families, including pre and post-operative teaching, wound care, ostomy care, and ostomy appliance maintenance/trouble-shooting. Requires a RN license and typically requires CWOCN, CWS, or CWCA certification. Typically requires a bachelor's degree in nursing. Typically reports to a supervisor or manager. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Wound and Enterostomal Salaries in Greenville, SCAlternate Job Titles:Nurse - Enterostomal Specialist, Nurse - Enterostomal Therapist, Staff Nurse - RN - Wound and EnterostomalCategory : Healthcare - Practitioners
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Provides professional nursing care to assigned patients in the emergency room. Triages each patient and determines priority of care based on physical, psychological, and social needs. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and emergency procedures, operating and monitoring medical equipment as necessary. Observes patients' progress, records observations in patient medical record, and updates attending physician directly when necessary. Typically requires a bachelor's degree. Requires Registered Nurse (RN). Requires Advanced Cardiac Life Support (ACLS). Typically reports to a manager or head of a unit/department. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Emergency Room Salaries in Greenville, SCAlternate Job Titles:Registered Nurse (RN), Emergency Room, Staff Nurse - RN - Emergency RoomCategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients with varying levels of mental health disorders and/or intellectual and developmental disabilities, including outpatients and psychiatric inpatients. Works as part of an interdisciplinary medical team to evaluate patients and develop treatment plans. Administers medications, monitors patient progress, and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. Renders all services in compliance with industry standards, privacy laws, and regulatory requirements. May supervise lower-level nurses. May require a bachelor's degree in nursing. Requires Registered Nurse (RN). Typically reports to a manager or head of a unit/department. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Psychiatric Salaries in Greenville, SCAlternate Job Titles:Psychiatric Nurse, Registered Psychiatric Nurse (RPN), Staff Nurse - RN - Behavioral Health, Staff Nurse - RN - PsychiatricCategory : Healthcare - Nursing