What is the average Registered Nurse salary for Greenville, SC?
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As of June 01, 2026, the average Registered Nurse salary in Greenville, SC is $110,114. The chart below represents localized salaries for some of our most popular Registered Nurse job titles in Greenville, SC. Salaries can vary greatly depending on numerous factors, including position, location, years of experience, and level of education. Salary.com’s team of Certified Compensation Professionals analyzed survey data collected from thousands of HR departments at companies of all sizes and industries to compile a range of salaries for various Registered Nurse job titles in Greenville, SC. Apply your personal criteria to one of the job titles below to get your personalized salary estimate.
Registered Nurse Salaries in Greenville, SC
| Job Title | Salary | Hourly Rate | Location | Date Updated |
| Telemedicine Registered Nurse | $93,446 | $44.93 | Greenville, SC | June 01, 2026 |
| Staff Nurse - RN II | $84,281 | $40.52 | Greenville, SC | June 01, 2026 |
| Staff Nurse - RN III | $97,415 | $46.83 | Greenville, SC | June 01, 2026 |
| Registered Nurse - Phone Triage | $83,688 | $40.23 | Greenville, SC | June 01, 2026 |
| Travel Nurse - RN | $137,997 | $66.34 | Greenville, SC | June 01, 2026 |
| Float Nurse - RN | $92,922 | $44.67 | Greenville, SC | June 01, 2026 |
| Staff Nurse - RN I | $69,387 | $33.36 | Greenville, SC | June 01, 2026 |
| Staff Nurse - RN - Emergency Room | $76,754 | $36.90 | Greenville, SC | June 01, 2026 |
| Nurse Practitioner - Emergency Room | $126,853 | $60.99 | Greenville, SC | June 01, 2026 |
| Nurse Practitioner - Pediatric | $119,055 | $57.24 | Greenville, SC | June 01, 2026 |
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Provides and manages care for patients remotely using telemedicine technology and tools. Follows nursing protocols in assessing patient condition, identifying needs, and answering patient questions. Collaborates with physicians to assess and direct patients to the appropriate level of medical care delivery. Utilizes video conferencing, mobile health applications, and remote patient monitoring devices to collect and record health data. Requires a bachelor's degree in nursing. Requires Registered Nurse (RN). Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4 -7 years of related experience. Telemedicine Registered Nurse Salaries in Greenville, SCAlternate Job Titles:Telemedicine Staff Nurse (RN), Telemedicine Registered Nurse
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN II Salaries in Greenville, SCAlternate Job Titles:Intermediate Registered Nurse - Staff, Registered Nurse (RN), Level 2, Staff Nurse - RN IICategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May focus on a specific medical specialty. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4-7 years of related experience. Staff Nurse - RN III Salaries in Greenville, SCAlternate Job Titles:Registered Nurse (RN), Level 3, Senior Registered Nurse - Staff, Staff Nurse - RN IIICategory : Healthcare - Nursing
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Provides nursing triage services and health advice to patients over the phone. Conducts patient assessments according to standard protocol. Uses clinical knowledge, experience, and best practices to provide medical advice, referrals, and care delivery. Follows established procedures and protocols for escalation and documentation. Typically requires a bachelor's degree in nursing. Requires Registered Nurse (RN). Typically reports to a supervisor. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4 -7 years of related experience. Registered Nurse - Phone Triage Salaries in Greenville, SCAlternate Job Titles:Medical Contact Center Nurse, Nurse Call Center RN, Registered Nurse (RN), Telephone Triage, Registered Nurse - Phone TriageCategory : Healthcare - Practitioners
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Responsible for helping hospitals, clinics, and other facilities maintain high standards of care and normal patient loads during periods of short staffing, seasonal peaks, or crises. Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment, as necessary. Observes patients' progress and records observations in patient medical records. Typically requires a bachelor's degree in nursing. Requires a Registered Nurse (RN) license. Typically reports to a manager. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Travel Nurse - RN Salaries in Greenville, SCAlternate Job Titles:Traveling Registered Nurse, Travel Nurse - RNCategory : Healthcare - Practitioners
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Responsible for providing professional nursing care to assigned patients across multiple departments or units within a healthcare facility, stepping in wherever there is a staffing shortage or increased patient demand. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment, as necessary. Observes patients' progress and records observations in patient medical records. Typically requires a bachelor's degree in nursing. Requires a Registered Nurse (RN) license. Typically reports to a manager. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Float Nurse - RN Salaries in Greenville, SCAlternate Job Titles:Float Pool Registered Nurse, Float Nurse - RNCategory : Healthcare - Practitioners
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is closely managed. Works on projects/matters of limited complexity in a support role. Typically requires 0-2 years of related experience. Staff Nurse - RN I Salaries in Greenville, SCAlternate Job Titles:Entry Registered Nurse - Staff, Registered Nurse (RN), Level 1, Staff Nurse - RN ICategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients in the emergency room. Triages each patient and determines priority of care based on physical, psychological, and social needs. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and emergency procedures, operating and monitoring medical equipment as necessary. Observes patients' progress, records observations in patient medical record, and updates attending physician directly when necessary. Typically requires a bachelor's degree. Requires Registered Nurse (RN). Requires Advanced Cardiac Life Support (ACLS). Typically reports to a manager or head of a unit/department. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Emergency Room Salaries in Greenville, SCAlternate Job Titles:Registered Nurse (RN), Emergency Room, Staff Nurse - RN - Emergency RoomCategory : Healthcare - Nursing
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Works in collaboration with a physician to assess the physical needs of patients admitted to the emergency room. Orders, interprets, and records results of clinical tests and reports results to physicians. Prescribes medications and makes recommendations for other therapeutic forms of treatment. Requires a master's degree. Requires Certified Registered Nurse Practitioner (CRNP). Requires Registered Nurse (RN). Requires Advanced Cardiac Life Support (ACLS). Typically reports to a physician. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Nurse Practitioner - Emergency Room Salaries in Greenville, SCAlternate Job Titles:Emergency Room Nurse Practitioner (NP), Emergency Unit - Certified Registered Nurse Practitioner (CRNP), Nurse Practitioner - Emergency Room
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Works in collaboration with physicians to manage care for patients in a pediatric setting. Orders, interprets, and records results of clinical tests and reports results to physicians. Prescribes medications and makes recommendations for other therapeutic forms of treatment. Requires a master's degree. Requires Certified Registered Nurse Practitioner (CRNP). Requires Registered Nurse (RN). Typically reports to a manager or head of a unit/department. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Nurse Practitioner - Pediatric Salaries in Greenville, SCAlternate Job Titles:Pediatric - Certified Registered Nurse Practitioner (CRNP), Pediatric Nurse Practitioner (NP), Nurse Practitioner - Pediatric