What is the average Nurse Practioner salary for Sioux Falls, SD?
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As of June 01, 2026, the average Nurse Practioner salary in Sioux Falls, SD is $75,709. The chart below represents localized salaries for some of our most popular Nurse Practioner job titles in Sioux Falls, SD. Salaries can vary greatly depending on numerous factors, including position, location, years of experience, and level of education. Salary.com’s team of Certified Compensation Professionals analyzed survey data collected from thousands of HR departments at companies of all sizes and industries to compile a range of salaries for various Nurse Practioner job titles in Sioux Falls, SD. Apply your personal criteria to one of the job titles below to get your personalized salary estimate.
Nurse Practioner Salaries in Sioux Falls, SD
| Job Title | Salary | Hourly Rate | Location | Date Updated |
| Staff Nurse - RN II | $82,669 | $39.74 | Sioux Falls, SD | June 01, 2026 |
| Staff Nurse - RN III | $95,551 | $45.94 | Sioux Falls, SD | June 01, 2026 |
| Staff Nurse - RN - Occupational Health | $86,757 | $41.71 | Sioux Falls, SD | June 01, 2026 |
| Staff Nurse Senior- RN - Occupational Health | $97,704 | $46.97 | Sioux Falls, SD | June 01, 2026 |
| School Nurse | $53,125 | $25.54 | Sioux Falls, SD | June 01, 2026 |
| Charge Nurse | $88,620 | $42.61 | Sioux Falls, SD | June 01, 2026 |
| Forensic Nurse - RN | $91,332 | $43.91 | Sioux Falls, SD | June 01, 2026 |
| Telemedicine Registered Nurse | $91,658 | $44.07 | Sioux Falls, SD | June 01, 2026 |
| Appeal Resolution Nurse | $84,589 | $40.67 | Sioux Falls, SD | June 01, 2026 |
| Float Nurse - RN | $91,145 | $43.82 | Sioux Falls, SD | June 01, 2026 |
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN II Salaries in Sioux Falls, SDAlternate Job Titles:Intermediate Registered Nurse - Staff, Registered Nurse (RN), Level 2, Staff Nurse - RN IICategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May focus on a specific medical specialty. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4-7 years of related experience. Staff Nurse - RN III Salaries in Sioux Falls, SDAlternate Job Titles:Registered Nurse (RN), Level 3, Senior Registered Nurse - Staff, Staff Nurse - RN IIICategory : Healthcare - Nursing
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Provides professional nursing care to on-site employees. Treats occupational injuries and illnesses, referring patients to emergency care facilities or outside medical resources as needed. Performs pre-employment physical examinations, including vision and hearing screenings, blood work, and other related tests. Maintains employee medical records and ensures that record keeping procedures comply with legal and confidentiality requirements. May be responsible for administering flu vaccinations, workers' compensation, disability, and/or employee health and safety training programs. Requires a bachelor's degree in nursing or equivalent. Requires a Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN - Occupational Health Salaries in Sioux Falls, SDAlternate Job Titles:Occupational Health Unit Nurse, RN - Occupational Health, Staff Nurse - RN - Occupational Health
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Provides professional nursing care to on-site employees. Treats occupational injuries and illnesses, referring patients to emergency care facilities or outside medical resources as needed. Performs pre-employment physical examinations, including vision and hearing screenings, blood work, and other related tests. Maintains employee medical records and ensures that record-keeping procedures comply with legal and confidentiality requirements. May be responsible for administering flu vaccination, workers' compensation, disability, and/or employee health and safety training programs. Typically requires a bachelor's degree in nursing or equivalent. Requires a Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4-7 years of related experience. Staff Nurse Senior- RN - Occupational Health Salaries in Sioux Falls, SDAlternate Job Titles:Senior Occupational Health Unit Nurse, Senior RN - Occupational Health, Staff Nurse Senior- RN - Occupational Health
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Provides nursing care to students and staff within a school setting. Responsible for assessing student health, providing first aid and emergency care, administering medications, managing chronic conditions, and educating students and staff on health-related topics. Focuses on promoting health and preventing illness to ensure a safe and healthy learning environment. Requires an associate degree in nursing. Requires Registered Nurse (RN). Typically reports to a school principal. Work is closely managed. Works on projects/matters of limited complexity in a support role. Typically requires 0-2 years of related experience. School Nurse Salaries in Sioux Falls, SDAlternate Job Titles:In- School Nurse (RN), School NurseCategories : Healthcare - Practitioners , Education , Healthcare - Nursing , Non-Profit and Social Services
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Plans, directs, and evaluates the overall nursing care and functions in a particular nursing unit or during an assigned shift. Coordinates the activities of the unit and directs, organizes, and assigns work to the nursing staff. Assesses, monitors, and educates the nursing staff on patient care. Institutes emergency procedures as necessary. Requires a bachelor's degree in nursing. Requires Registered Nurse (RN). Typically requires Advanced Cardiac Life Support (ACLS). Typically reports to a manager. Supervises a small group of para-professional staff in an organization characterized by highly transactional or repetitive processes. Contributes to the development of processes and procedures. Typically requires 3 years experience in the related area as an individual contributor. Thorough knowledge of functional area under supervision. Charge Nurse Salaries in Sioux Falls, SDAlternate Job Titles:Patient Placement/Charge Nurse, Shift Charge Nurse, Charge Nurse
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Provides compassionate, trauma-informed medical care to patients after an assault. Collects and documents forensic evidence and findings to support investigations and court proceedings. Assesses and treats injuries and may provide medications for sexually transmitted infection (STI) prevention and emergency contraception. May testify in court as expert witnesses and coordinate with law enforcement and advocacy services. Typically requires a bachelor's degree in nursing Requires a Registered Nurse (RN) license.. Typically reports to a manager. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Forensic Nurse - RN Salaries in Sioux Falls, SDAlternate Job Titles:Forensic Nurse Examiner, Forensic Nurse - RN
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Provides and manages care for patients remotely using telemedicine technology and tools. Follows nursing protocols in assessing patient condition, identifying needs, and answering patient questions. Collaborates with physicians to assess and direct patients to the appropriate level of medical care delivery. Utilizes video conferencing, mobile health applications, and remote patient monitoring devices to collect and record health data. Requires a bachelor's degree in nursing. Requires Registered Nurse (RN). Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4 -7 years of related experience. Telemedicine Registered Nurse Salaries in Sioux Falls, SDAlternate Job Titles:Telemedicine Staff Nurse (RN), Telemedicine Registered Nurse
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Conducts the medical review activities needed to resolve and process clinical appeals and claims. Reviews applicable medical records and assesses clinical data to investigate and resolve disputes over the medical necessity for services, approvals, pre-certifications, or other cases. Understands and interprets applicable medical terminology, clinical procedures, regulations and policies. Documents cases according to guidelines and standard procedures. Prepares the documentation required for further medical review, hearings, and different appeal processes. Typically requires a bachelor's degree in nursing or equivalent. Requires a Registered Nurse (RN) license. Typically reports to a manager. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4 -7 years of related experience. Appeal Resolution Nurse Salaries in Sioux Falls, SDAlternate Job Titles:Grievance and Appeals Resolution Nurse, Appeal Resolution NurseCategory : Healthcare - Administrative
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Responsible for providing professional nursing care to assigned patients across multiple departments or units within a healthcare facility, stepping in wherever there is a staffing shortage or increased patient demand. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment, as necessary. Observes patients' progress and records observations in patient medical records. Typically requires a bachelor's degree in nursing. Requires a Registered Nurse (RN) license. Typically reports to a manager. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Float Nurse - RN Salaries in Sioux Falls, SDAlternate Job Titles:Float Pool Registered Nurse, Float Nurse - RNCategory : Healthcare - Practitioners