What is the average Staff Nurse Rn salary for Sioux Falls, SD?
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As of August 01, 2026, the average Staff Nurse Rn salary in Sioux Falls, SD is $86,128. The chart below represents localized salaries for some of our most popular Staff Nurse Rn job titles in Sioux Falls, SD. Salaries can vary greatly depending on numerous factors, including position, location, years of experience, and level of education. Salary.com’s team of Certified Compensation Professionals analyzed survey data collected from thousands of HR departments at companies of all sizes and industries to compile a range of salaries for various Staff Nurse Rn job titles in Sioux Falls, SD. Apply your personal criteria to one of the job titles below to get your personalized salary estimate.
Staff Nurse Rn Salaries in Sioux Falls, SD
| Job Title | Salary | Hourly Rate | Location | Date Updated |
| Staff Nurse - RN II | $83,072 | $39.94 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN III | $96,029 | $46.17 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Occupational Health | $87,218 | $41.93 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Hospice | $85,311 | $41.02 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Geriatric | $75,146 | $36.13 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Burn | $73,745 | $35.45 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Research | $89,393 | $42.98 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Pediatrics | $76,295 | $36.68 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Oncology | $80,248 | $38.58 | Sioux Falls, SD | August 01, 2026 |
| Staff Nurse - RN - Obstetrics | $76,535 | $36.80 | Sioux Falls, SD | August 01, 2026 |
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN II Salaries in Sioux Falls, SDAlternate Job Titles:Intermediate Registered Nurse - Staff, Registered Nurse (RN), Level 2, Staff Nurse - RN IICategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. May focus on a specific medical specialty. May require a bachelor's degree in nursing. Requires a valid state Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Work is generally independent and collaborative in nature. Contributes to moderately complex aspects of a project. Typically requires 4-7 years of related experience. Staff Nurse - RN III Salaries in Sioux Falls, SDAlternate Job Titles:Registered Nurse (RN), Level 3, Senior Registered Nurse - Staff, Staff Nurse - RN IIICategory : Healthcare - Nursing
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Provides professional nursing care to on-site employees. Treats occupational injuries and illnesses, referring patients to emergency care facilities or outside medical resources as needed. Performs pre-employment physical examinations, including vision and hearing screenings, blood work, and other related tests. Maintains employee medical records and ensures that record keeping procedures comply with legal and confidentiality requirements. May be responsible for administering flu vaccinations, workers' compensation, disability, and/or employee health and safety training programs. Requires a bachelor's degree in nursing or equivalent. Requires a Registered Nurse (RN) license. Typically reports to a manager or head of a unit/department. Occasionally directed in several aspects of the work. Gaining exposure to some of the complex tasks within the job function. Typically requires 2-4 years of related experience. Staff Nurse - RN - Occupational Health Salaries in Sioux Falls, SDAlternate Job Titles:Occupational Health Unit Nurse, RN - Occupational Health, Staff Nurse - RN - Occupational Health
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Provides professional nursing care to assigned terminally ill patients in a hospice environment. Records patient histories, performs various diagnostic tests, administers medications, and develops patient care plans in conjunction with other medical professionals. Performs examinations and prescribed procedures, operating and monitoring medical equipment as necessary. Observes patients' condition and records observations in patient medical records. Typically requires a bachelor's degree in nursing.Typically reports to a manager or head of a unit/department. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Hospice Salaries in Sioux Falls, SDAlternate Job Titles:Registered Nurse (RN), Hospice, Staff Nurse - RN - Hospice
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Provides professional nursing care to assigned geriatric patients. Records patient histories, performs various diagnostic tests, administers medications, and develops geriatric care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. Typically requires a bachelor's degree in nursing.Typically reports to a manager or head of a unit/department. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Geriatric Salaries in Sioux Falls, SDAlternate Job Titles:Registered Nurse (RN), Geriatric, Staff Nurse - RN - GeriatricCategory : Healthcare - Nursing
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Provides professional nursing care to assigned patients in the burn unit. Examines, prepares, cleans, and dresses patient burn wounds. Evaluates, plans, and documents nursing care for burn patients, as needed. Promotes patients' well-being by teaching patients and families to understand burn wound conditions, medications, and self-care skills. May administer medication and IV treatments to alleviate patients' pain and discomfort. Typically requires a bachelor's degree in nursing. Typically reports to a manager or head of a unit/department. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Burn Salaries in Sioux Falls, SDAlternate Job Titles:Registered Nurse - Burn Unit (RN), Staff Nurse - RN - Burn
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Evaluates, plans, implements, and documents scientific research utilizing human subjects. Gathers data and analyzes results. May be responsible for participant recruitment and counseling, ethical oversight, or compilation of study results. Typically requires a bachelor's degree in nursing. Requires a valid state RN license. Typically reports to a manager or head of a unit/department. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Research Salaries in Sioux Falls, SDAlternate Job Titles:Clinical Research Nurse Leader, Staff Nurse - RN - Research
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Provides professional nursing care to assigned pediatric patients. Records patient histories, performs various diagnostic tests, administers medications, and develops pediatric patient care plans in conjunction with other medical professionals. Assists physicians during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Promotes patients' independence by teaching patients and families to understand conditions, medications, and self-care skills. Typically requires a bachelor's degree in nursing. Typically reports to a manager or head of a unit/department. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Pediatrics Salaries in Sioux Falls, SDAlternate Job Titles:Pediatric Nurse, Registered Nurse (RN), Pediatrics, Staff Nurse - RN - PediatricsCategory : Healthcare - Practitioners
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Provides professional nursing care to assigned oncology patients. Records patient histories, performs various diagnostic tests, administers medications including chemotherapy, and develops patient care plans in conjunction with other medical professionals. Assists oncologists during examinations and procedures, operating and monitoring medical equipment as necessary. Observes patients' progress and records observations in patient medical records. Teaches patients and families about conditions and treatment options. Typically requires a bachelor's degree in nursing. Typically reports to a manager or head of a unit/department. May require ONS/ONCC certification to deliver chemotherapy. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Oncology Salaries in Sioux Falls, SDAlternate Job Titles:Oncology Nurse, Registered Nurse (RN), Oncology, Staff Nurse - RN - OncologyCategory : Healthcare - Nursing
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Provides professional nursing care to assigned OB/GYN patients. Assists physicians with examinations, labor and delivery, operates and monitors medical equipment, and records relevant statistics, including time of birth. Provides immediate and comprehensive care to mothers and newborns during antepartum, intrapartum and postpartum periods. Observes patient's condition, records observations in patient medical record, and updates attending physician directly when necessary. May administer medications and IV solutions as necessary. Typically requires a bachelor's degree in nursing. Typically reports to a manager or head of a unit/department. Typically requires Neonatal Resuscitation Program (NRP) certification. Requires a valid state RN license. Years of experience may be unspecified. Certification and/or licensing in the position's specialty is the main requirement. Staff Nurse - RN - Obstetrics Salaries in Sioux Falls, SDAlternate Job Titles:Labor and Delivery Nurse, Obstetrics/Delivery Nurse, Staff Nurse - RN - ObstetricsCategory : Healthcare - Nursing