What are the main factors that influence a Drug Safety Manager's salary?

The primary factors are: 1) Experience Level, 2) Geographic Location, 3) Education/Skills, 4) Company Size & Industry

How does experience change A Drug Safety Manager's salary?

A Drug Safety Manager's salary grows with experience: starting around $93,243 for beginners, reaching about $95,472 at mid-level, and approach $100,429 for experts.

What are the highest paying states for a Drug Safety Manager?

Drug Safety Manager salary varies significantly by state. The top 3 highest paying states for Drug Safety Manager roles are District of Columbia $110,816, California $110,396, Massachusetts $108,925. These tech hubs typically pay 10-15% above the national average.

How much do different types of Drug Safety Manager roles make?

Salaries for Drug Safety Manager level roles vary by specialization: Drug Safety Monitoring and Information Manager, Sr.: $145,900; Drug Safety/Medical Information Manager, Sr.: $145,850; Drug Safety Assessment Manager, Sr.: $145,846; Drug Safety Monitoring and Information Manager: $138,200; Drug Safety/Medical Information Manager: $138,180.

Drug Safety Manager Salary in the United States

How much does a Drug Safety Manager make in the United States? As of September 01, 2026, the average salary for a Drug Safety Manager in the United States is $100,087 per year, which breaks down to an hourly rate of $48.

However, a Drug Safety Manager's salary can vary significantly. Here's a look at the typical salary range:

Top Earners (90th percentile): $123,551
Majority Range (25th-75th percentile): $89,129 to $112,369
Entry-Level (10th percentile): $79,153

10% $79,153

50% (Median) $100,087

90% $123,551

Drug Safety Manager Salaries by Percentile

	Annual Salary	Monthly Pay	Weekly Pay	Hourly Wage
75th Percentile	$112,369	$9,364	$2,161	$54
Average	$100,087	$8,341	$1,925	$48
25th Percentile	$89,129	$7,427	$1,714	$43

Salary Factors Salary-Boosting Skills Salary by Experience Related Job Salaries Top Paying Cities Explore Related Jobs

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Key Factors That Influence Drug Safety Manager Salaries

A Drug Safety Manager's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.

How Experience Level Affects Drug Safety Manager Salaries?

Experience is a primary driver of a Drug Safety Manager's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

Entry-Level (less than 1 year): $93,243
Early Career (1-2 years): $93,758
Mid-Level (2-4 years): $95,472
Senior-Level (5-8 years): $97,529
Expert (over 8 years): $100,429

Job Role	Years of Experience	Average Salary
Entry Level Drug Safety Manager	less than 1 year	$93,243
Early Career Level Drug Safety Manager	1-2 years	$93,758
Mid-Level Level Drug Safety Manager	2-4 years	$95,472
Senior-Level Level Drug Safety Manager	5-8 years	$97,529
Expert Level Drug Safety Manager	over 8 years	$100,429

How Do Drug Safety Manager Salaries Vary from State to State?

Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Drug Safety Managers. For example, consider the average annual salaries in these key locations:

District of Columbia: $110,816.
California: $110,396.
Massachusetts: $108,925.

District of Columbia $110,816 California $110,396 Massachusetts $108,925 Washington $108,524 New Jersey $108,484 Alaska $108,344 Connecticut $106,963 New York $106,402

Hawaii $104,611 Rhode Island $103,770 Maryland $103,200 Minnesota $102,419 Colorado $102,119 Illinois $102,019 Oregon $101,638 Delaware $101,358

New Hampshire $101,182 Virginia $100,788 Pennsylvania $99,637 Nevada $99,056 North Dakota $98,866 Michigan $98,566 Wisconsin $98,456 Vermont $98,235

Texas $97,625 Maine $97,585 Arizona $97,525 Ohio $97,455 Georgia $96,534 Indiana $96,074 Wyoming $95,983 Utah $95,843

Iowa $95,783 Kansas $95,303 Louisiana $95,163 North Carolina $95,113 Missouri $95,093 Florida $94,702 Montana $94,492 Nebraska $94,292

Kentucky $94,182 South Carolina $93,782 Tennessee $93,531 Idaho $93,431 New Mexico $92,701 Oklahoma $92,540 Alabama $91,950 South Dakota $90,959

Arkansas $90,419 West Virginia $90,128 Mississippi $89,258

Top Paying Cities for Drug Safety Manager

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

San Jose: $126,240
San Francisco: $124,858
Oakland: $122,226

San Jose, CA $126,240

San Francisco, CA $124,858

Oakland, CA $122,226

New York, NY $115,239

Paramus, NJ $113,838

Queens Village, NY $113,833

Passaic, NJ $113,738

Bergenfield, NJ $113,729

Stamford, CT $113,509

Huntington, NY $113,468

Newark, NJ $112,728

Bridgeport, CT $112,517

Vallejo, CA $112,318

New Brunswick, NJ $112,278

Petaluma, CA $112,218

Middlesex, NJ $112,027

Somerset, NJ $111,957

Santa Cruz, CA $111,827

Boston, MA $111,217

Monterey, CA $110,865

Seattle, WA $110,636

Santa Rosa, CA $110,616

Los Angeles, CA $110,586

Juneau, AK $110,326

Washington, DC $110,216

Orange, CA $109,859

Santa Ana, CA $109,595

Long Beach, CA $109,495

Anaheim, CA $109,475

Anchorage, AK $109,425

Santa Maria, CA $109,125

Everett, WA $109,105

Danbury, CT $108,753

Bremerton, WA $108,614

Tacoma, WA $108,254

New Suffolk, NY $108,252

Sacramento, CA $108,224

Santa Barbara, CA $108,114

San Diego, CA $108,004

Trenton, NJ $108,004

Brockton, MA $107,894

Fairbanks, AK $107,649

Lompoc, CA $107,393

Lowell, MA $107,312

Ventura, CA $107,293

Nashua, NH $107,273

Stockton, CA $107,263

Modesto, CA $106,533

Poughkeepsie, NY $106,312

Olympia, WA $106,122

Kennewick, WA $106,122

New Haven, CT $106,082

Lawrence, MA $105,722

Hartford, CT $105,622

Riverside, CA $105,602

New Bedford, MA $105,502

Richland, WA $105,502

Bakersfield, CA $105,362

San Bernardino, CA $105,322

New Britain, CT $105,312

Atlantic City, NJ $105,312

New London, CT $105,272

Norwich, CT $105,241

Portsmouth, NH $105,221

Boulder, CO $105,009

Portland, OR $104,871

Worcester, MA $104,861

Minneapolis, MN $104,551

Philadelphia, PA $104,411

Honolulu, HI $104,080

Saint Paul, MN $104,032

Vineland, NJ $104,010

Providence, RI $103,720

Chicago, IL $103,430

Bellingham, WA $103,310

Springfield, MA $103,230

Baltimore, MD $103,200

Chico, CA $102,949

Pittsfield, MA $102,679

Manchester, NH $102,489

Spokane, WA $102,049

Denver, CO $102,039

Albany, NY $101,568

Troy, NY $101,528

Nassau, NY $101,421

Schenectady, NY $101,318

Wilmington, DE $101,238

Burlington, VT $101,098

Salem, OR $101,058

Portland, ME $100,748

Yakima, WA $100,647

Rochester, MN $100,337

Reno, NV $100,287

Fresno, CA $100,287

Milwaukee, WI $100,197

Detroit, MI $100,097

Ann Arbor, MI $100,080

Allentown, PA $100,067

Colorado Springs, CO $99,897

Syracuse, NY $99,847

Carson City, NV $99,847

Houston, TX $99,707

Eugene, OR $99,657

Gary, IN $99,537

Springfield, OR $99,456

Bismarck, ND $99,436

Galveston, TX $99,366

Medford, OR $99,216

Fort Collins, CO $99,176

Concord, NH $99,126

Austin, TX $99,096

Mesa, AZ $98,886

Reading, PA $98,876

Phoenix, AZ $98,866

Dallas, TX $98,836

Saint Cloud, MN $98,740

Madison, WI $98,606

Utica, NY $98,335

Rochester, NY $98,175

Des Moines, IA $98,165

Raleigh, NC $98,155

Atlanta, GA $98,005

Battle Creek, MI $97,975

Salt Lake City, UT $97,945

Lancaster, PA $97,795

Harrisburg, PA $97,655

Kansas City, MO $97,555

Kansas City, KS $97,535

Champaign, IL $97,535

Fort Worth, TX $97,525

Columbus, OH $97,508

Boca Raton, FL $97,485

Pittsburgh, PA $97,445

Richmond, VA $97,405

Indianapolis, IN $97,385

Cleveland, OH $97,375

Las Vegas, NV $97,255

Cincinnati, OH $97,255

Petersburg, VA $97,104

Huntsville, AL $96,954

Lansing, MI $96,887

Lebanon, PA $96,874

Pueblo, CO $96,864

Appleton, WI $96,834

Buffalo, NY $96,794

Dayton, OH $96,764

Racine, WI $96,744

Charlotte, NC $96,734

Saint Louis, MO $96,704

York, PA $96,644

Elkhart, IN $96,644

Gastonia, NC $96,625

Billings, MT $96,601

Beaumont, TX $96,574

Lorain, OH $96,554

Benton Harbor, MI $96,534

Toledo, OH $96,514

Binghamton, NY $96,464

Rock Hill, SC $96,454

Rockford, IL $96,404

Springfield, IL $96,364

Elyria, OH $96,354

Fargo, ND $96,354

Flagstaff, AZ $96,284

Fort Lauderdale, FL $96,224

Duluth, MN $96,164

Miami, FL $96,164

Grand Forks, ND $96,094

Cheyenne, WY $96,094

Bangor, ME $95,873

Cedar Rapids, IA $95,763

Durham, NC $95,721

Louisville, KY $95,713

Grand Rapids, MI $95,693

Hialeah, FL $95,683

Casper, WY $95,543

Scranton, PA $95,423

New Orleans, LA $95,393

Virginia Beach, VA $95,383

Akron, OH $95,333

Peoria, IL $95,203

Sarasota, FL $95,183

Nashville, TN $95,113

Omaha, NE $95,113

Green Bay, WI $95,113

Baton Rouge, LA $95,063

Charleston, SC $95,043

Davenport, IA $94,993

Jamestown, NY $94,993

Tucson, AZ $94,943

Saint Petersburg, FL $94,882

Tampa, FL $94,862

Evansville, IN $94,802

Port Arthur, TX $94,802

Bradenton, FL $94,762

Santa Fe, NM $94,582

Orlando, FL $94,402

Clearwater, FL $94,372

La Crosse, WI $94,162

Canton, OH $94,162

Albuquerque, NM $94,102

Newport News, VA $94,092

High Point, NC $94,062

Ogden, UT $94,022

Corpus Christi, TX $93,942

Norfolk, VA $93,882

Laramie, WY $93,882

Rock Island, IL $93,822

Saginaw, MI $93,802

Jacksonville, FL $93,792

Salisbury, NC $93,772

Boise, ID $93,751

Moline, IL $93,701

Fort Myers, FL $93,671

Memphis, TN $93,651

Tulsa, OK $93,601

Waterloo, IA $93,541

Spartanburg, SC $93,441

Lincoln, NE $93,391

Fort Wayne, IN $93,371

Provo, UT $93,361

Cedar Falls, IA $93,241

San Antonio, TX $93,201

Greensboro, NC $93,161

South Bend, IN $93,151

Savannah, GA $93,041

Muskegon, MI $93,001

Birmingham, AL $92,991

Winston Salem, NC $92,942

Lake Charles, LA $92,701

Anderson, IN $92,681

Lexington, KY $92,651

Augusta, GA $92,621

Greenville, SC $92,621

Lima, OH $92,540

Wichita, KS $92,530

Tuscaloosa, AL $92,530

Columbia, SC $92,440

Springfield, OH $92,420

Asheville, NC $92,260

Bloomington, IN $92,190

Knoxville, TN $91,830

Shreveport, LA $91,820

Wilmington, NC $91,690

Roanoke, VA $91,690

Topeka, KS $91,510

Frankfort, KY $91,499

Oklahoma City, OK $91,429

Chillicothe, OH $91,389

Longview, TX $91,379

Melbourne, FL $91,369

Sioux Falls, SD $91,209

Mobile, AL $91,199

Terre Haute, IN $91,159

Altoona, PA $91,099

Amarillo, TX $91,029

Killeen, TX $90,999

Fayetteville, AR $90,919

Chattanooga, TN $90,889

Sioux City, IA $90,799

Idaho Falls, ID $90,779

Lynchburg, VA $90,699

Gainesville, FL $90,569

Portsmouth, OH $90,519

Little Rock, AR $90,499

Lafayette, LA $90,459

Youngstown, OH $90,459

Daytona Beach, FL $90,399

Clarksville, TN $90,389

Pensacola, FL $90,379

Temple, TX $90,372

Hopkinsville, KY $90,078

Erie, PA $90,058

Florence, SC $90,018

Charleston, WV $89,858

Great Falls, MT $89,808

Macon, GA $89,668

Tallahassee, FL $89,658

Fayetteville, NC $89,638

Waco, TX $89,618

Helena, MT $89,548

Pine Bluff, AR $89,510

Vincennes, IN $89,388

Lubbock, TX $89,348

Alamogordo, NM $89,288

Twin Falls, ID $89,198

Rapid City, SD $89,168

Jackson, MS $88,987

Huntington, WV $88,980

Greenville, MS $88,977

Parkersburg, WV $88,875

Montgomery, AL $88,857

Wichita Falls, TX $88,757

Springfield, MO $88,757

Biloxi, MS $88,707

Monroe, LA $88,607

Johnstown, PA $88,537

Sumter, SC $88,497

Columbus, GA $88,487

Pascagoula, MS $88,297

Abilene, TX $88,297

Kingsport, TN $88,037

Albany, GA $88,037

Gulfport, MS $88,006

Alexandria, LA $87,676

Fort Smith, AR $87,426

El Paso, TX $87,156

Las Cruces, NM $86,705

Harlingen, TX $86,451

Pocatello, ID $86,435

Florence, AL $86,305

Brownsville, TX $86,285

Mcallen, TX $86,075

Dothan, AL $85,935

Columbus, MS $85,340

Altus, OK $84,874

Lawton, OK $84,684

Pierre, SD $84,323

Drug Safety Manager Salary by Industry: Top Paying Sectors

For Drug Safety Manager roles, the industry you choose can affect earning potential by as much as 30% (the gap between the highest and lowest paying industries). Data shows that the Edu., Gov't. & Nonprofit and Insurance sectors offer the strongest compensation, at 10% above the average. In contrast, Drug Safety Manager positions in Business Services or Financial Services typically offer lower base pay, as these industries often view Drug Safety Manager as a support function rather than a direct revenue driver.

The top paying industries for a Drug Safety Manager

Industry Sector	Average Annual Salary	Average Hourly Rate	Pay vs.Avg
Edu., Gov't. & Nonprofit	$110,096	$53.0	10%
Insurance	$110,096	$53.0	10%

Drug Safety Manager Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Drug Safety Manager's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

$89,129

Average $100,087/year

$112,369

$7,427

Average $8,341/month

$9,364

$1,714

Average $1,925/week

$2,161

$43

Average $48/hour

$54

	Annual Salary	Monthly Pay	Weekly Pay	Hourly Wage
75th Percentile	$112,369	$9,364	$2,161	$54
Average	$100,087	$8,341	$1,925	$48
25th Percentile	$89,129	$7,427	$1,714	$43

Salary Trends for Drug Safety Manager

Salaries for a Drug Safety Manager can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $101,237 in 2023 to around $100,228 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Drug Safety Manager salary trends, click here.

Average Annual Salary of Drug Safety Manager Over Time

$???
$101,237
$101,307
$100,228
$???
$???

2022
2023
2024
2025
2026
2027

Year	Average Annual Salary
2022	View More
2023	$101,237
2024	$101,307
2025	$100,228

Most common benefits for Drug Safety Manager

Social Security
401 (k)
Disability
Healthcare
Pension
Time Off (days)

Common company salaries for Drug Safety Manager

Here are companies hiring for Drug Safety Manager and their salaries, click below for more details.

K $114,295/per year

Kpmg Us LLP Business Services United States

W $114,096/per year

Warner Bros Discovery Business Services United States

D $111,927/per year

Dentsu International Ltd Business Services United States

G $111,873/per year

GroupM Worldwide Inc Business Services United States

C $111,651/per year

CoWorx Staffing Business Services United States

C $110,194/per year

Contemporary Services Corp Business Services United States

S $107,128/per year

Showcase Cinemas Business Services United States

A $106,429/per year

Amentum Services Inc Business Services United States

A $106,199/per year

Allied Universal Security Services LLC Business Services United States

S $106,104/per year

Sodexo USA Business Services United States

J $105,192/per year

JLL Technologies Business Services United States

I $104,478/per year

Intact Insurance Group USA LLC Business Services United States

N $101,619/per year

NielsenIQ Business Services United States

T $101,470/per year

The Leading Edge Alliance Business Services United States

H $101,308/per year

Honeywell UOP Business Services United States

R $97,720/per year

Reeve & Associates Business Services United States

M $97,584/per year

ManpowerGroup Global Inc Business Services United States

F $95,980/per year

Financial Sys Nco Business Services United States

A $95,314/per year

Arrow Global Ltd Business Services United States

C $94,777/per year

CarMax Enterprise Services LLC Business Services United States

D $94,479/per year

DZConneX Business Services United States

A $93,802/per year

Adecco Staffing, USA Business Services United States

R $92,937/per year

Resource MFG Business Services United States

Z $92,774/per year

Zachry Brands Inc Business Services United States

G $88,138/per year

Greystar Worldwide LLC Business Services United States

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FAQ about Drug Safety Manager

1. What industry pays the highest salary for Drug Safety Manager?

The Edu., Gov't. & Nonprofit industry offers the highest average compensation for Drug Safety Manager roles, with salaries approximately 10% above the market median.

Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

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Drug Safety Manager Salary in the United States

Check out Drug Safety Manager Job Openings in the United States

Key Factors That Influence Drug Safety Manager Salaries

How Experience Level Affects Drug Safety Manager Salaries?

How Do Drug Safety Manager Salaries Vary from State to State?

Top Paying Cities for Drug Safety Manager

Drug Safety Manager Salary by Industry: Top Paying Sectors

The top paying industries for a Drug Safety Manager

Drug Safety Manager Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Salary Trends for Drug Safety Manager

Average Annual Salary of Drug Safety Manager Over Time

Most common benefits for Drug Safety Manager

Common company salaries for Drug Safety Manager

Find Your Next Drug Safety Manager Job

For Employees

For Employers

FAQ about Drug Safety Manager

1. What industry pays the highest salary for Drug Safety Manager?

Where Does Our Salary Data Come From?

Are you an HR manager or compensation specialist?

Drug Safety Manager Salary in the United States

Check out Drug Safety Manager Job Openings in the United States

Key Factors That Influence Drug Safety Manager Salaries

How Experience Level Affects Drug Safety Manager Salaries?

How Do Drug Safety Manager Salaries Vary from State to State?

Top Paying Cities for Drug Safety Manager

Drug Safety Manager Salary by Industry: Top Paying Sectors

The top paying industries for a Drug Safety Manager

Drug Safety Manager Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Salaries of jobs related to Drug Safety Manager

Salary Trends for Drug Safety Manager

Average Annual Salary of Drug Safety Manager Over Time

Most common benefits for Drug Safety Manager

Common company salaries for Drug Safety Manager

Find Your Next Drug Safety Manager Job

For Employees

For Employers

FAQ about Drug Safety Manager

1. What industry pays the highest salary for Drug Safety Manager?

Where Does Our Salary Data Come From?

Are you an HR manager or compensation specialist?